Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis.

ABSTRACT: Missing heritability is a common problem in psychiatry that impedes precision medicine approaches to autism and other heritable complex disorders. This proof-of-concept study uses a systematic review and meta-analysis of the association between variants of the serotonin transporter promoter (5-HTTLPR) and autism to explore the hypothesis that some missing heritability can be explained using an optimum curve. A systematic literature search was performed to identify transmission disequilibrium tests on the short/long (S/L) 5-HTTLPR polymorphism in relation to autism. We analysed five American, seven European, four Asian and two American/European samples. We found no transmission preference in the joint samples and in Europe, preferential transmission of S in America and preferential transmis

SUBMITTER: Wegener Sleeswijk A 

PROVIDER: S-EPMC6829377 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature