Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond.

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology that primarily affects women of childbearing age. The development of SLE is attributed to the breach of immunological tolerance and the interaction between SLE-susceptibility genes and various environmental factors, resulting in the production of pathogenic autoantibodies. Working in concert with the innate and adaptive arms of the immune system, lupus-related autoantibodies mediate immune-complex deposition in various tissues and organs, leading to acute and chronic inflammation and consequent end-organ damage. Over the past two decades or so, the impact of genetic susceptibility on the development of SLE has been well demonstrated in a number of large-scale genetic association studies which have uncove

SUBMITTER: Kwon YC 

PROVIDER: S-EPMC6829439 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature