Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles.

ABSTRACT:

Background

Chronic liver diseases are frequently accompanied with activation of biliary epithelial cells (BECs) that can differentiate into hepatocytes and cholangiocytes, providing an endogenous back-up system. Functional studies on BECs often rely on isolations of an BEC cell population from healthy and/or injured livers. However, a consensus on the characterization of these cells has not yet been reached. The aim of this study was to compare the publicly available transcriptome profiles of human and mouse BECs and to establish gene signatures that can identify quiescent and activated human and mouse BECs.

Methods

We used publicly available transcriptome data sets of human and mouse BECs, compared their profiles and analyzed co-expressed genes and pathways. By merging both

SUBMITTER: Verhulst S 

PROVIDER: S-EPMC6829476 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature