Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses.

ABSTRACT: Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we examined surface coating with laminin in a standardized rat implantation model. Detergent-decellularized aortic grafts from donor rats (n = 37) were coated with laminin and systemically implanted into Wistar rats. Uncoated implants served as controls. Implant re-colonization and remodeling were examined by scanning electron microscopy (n = 10), histology and immunohistology (n = 18). Laminin coating persisted over eight weeks. Two weeks after implantation, no relevant neoendothelium formation was observed, whereas it was covering the whole grafts after eight

SUBMITTER: Toshmatova M 

PROVIDER: S-EPMC6829566 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature