The amygdala differentially regulates defensive behaviors evoked by CO₂.

ABSTRACT: CO₂ inhalation can provoke panic attacks in humans, and the likelihood is increased in patients with panic disorder. Identifying brain sites involved could provide important mechanistic insight into the illness. In mice, the amygdala has been suggested to promote CO₂ responses; however, recent studies in humans with amygdala damage indicate the amygdala is not required for CO₂-induced fear and panic and might actually oppose these responses. To clarify the role of the amygdala, we produced lesions in mice paralleling the human lesions, and characterized behavioral responses to CO₂. Compared to sham controls, we found that amygdala-lesioned mice froze less to 10% CO₂, and unlike shams they also began to jump frenetically. At 20% CO

SUBMITTER: Taugher RJ 

PROVIDER: S-EPMC6829583 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature