Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements.

ABSTRACT: In recent years, the introduction of new molecular techniques in experimental and clinical settings has allowed researchers and clinicians to propose circulating-tumor DNA (ctDNA) analysis and liquid biopsy as novel promising strategies for the early diagnosis of cancer and for the definition of patients' prognosis. It was widely demonstrated that through the non-invasive analysis of ctDNA, it is possible to identify and characterize the mutational status of tumors while avoiding invasive diagnostic strategies. Although a number of studies on ctDNA in patients' samples significantly contributed to the improvement of oncology practice, some investigations generated conflicting data about the diagnostic and prognostic significance of ctDNA. Hence, to highlight the relevant achievements obtai

SUBMITTER: Tuaeva NO 

PROVIDER: S-EPMC6829588 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature