Exploring Human Diseases and Biological Mechanisms by Protein Structure Prediction and Modeling.

ABSTRACT: Protein structure prediction and modeling provide a tool for understanding protein functions by computationally constructing protein structures from amino acid sequences and analyzing them. With help from protein prediction tools and web servers, users can obtain the three-dimensional protein structure models and gain knowledge of functions from the proteins. In this chapter, we will provide several examples of such studies. As an example, structure modeling methods were used to investigate the relation between mutation-caused misfolding of protein and human diseases including epilepsy and leukemia. Protein structure prediction and modeling were also applied in nucleotide-gated channels and their interaction interfaces to investigate their roles in brain and heart cells. In molecular mecha

SUBMITTER: Wang J 

PROVIDER: S-EPMC6829626 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature