The challenge of correctly reporting hormones content and secretion in isolated human islets.

ABSTRACT:

Background

An increased access of research laboratories to isolated human islets has improved our understanding of the biology of the endocrine pancreas and hence the mechanisms causing diabetes. However, in vitro studies of human islets remain technically challenging, and optimal use of such precious material requires a minimum of rigor and coordination to optimize the reliability and share of the information. A detailed report of the demographics of pancreas donors and of the procedures of islet handling after isolation is important but insufficient. Correct characterization of islet basic functions (a token of quality) at the time of experimentation is also crucial.

Scope of review

I have analyzed the literature reporting measurements of insulin and glucagon in the human

SUBMITTER: Henquin JC 

PROVIDER: S-EPMC6829677 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature