Comparative analysis of cellular expression pattern of schizophrenia risk genes in human versus mouse cortex.

ABSTRACT:

Background

Schizophrenia is a common psychiatric disease with high hereditary. The identification of schizophrenia risk genes (SRG) has shed light on its pathophysiological mechanisms. Mouse genetic models have been widely used to study the function of SRG in the brain with a cell type specific fashion. However, whether the cellular expression pattern of SRG is conserved between human and mouse brain is not thoroughly studied.

Results

We analyzed the single-cell transcription of 180 SRG from human and mouse primary visual cortex (V1). We compared the percentage of glutamatergic, GABAergic and non-neuronal cells that express each SRG between mouse and human V1 cortex. Thirty percent (54/180) of SRG had significantly different expression rate in glutamatergic neurons between m

SUBMITTER: Zhang HL 

PROVIDER: S-EPMC6829839 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature