A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer.

ABSTRACT:

Background

Circular RNAs (circRNAs), a novel type of noncoding RNAs, play critical roles in the initiation and progression of cancer. Emerging studies also shows that circRNAs may function as potential markers for cancer diagnosis and treatment. However, the diagnostic value of circRNAs in colorectal cancer (CRC) remains need to be unearthed.

Methods

CircRNA microarray was performed to detect the differentially expressed circRNAs in eight plasma samples, including four colorectal cancer (CRC) and four normal samples. Besides, the results of microarray were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, ROC curve evaluation was performed to calculate the diagnostic value of significantly dysregulated circRNAs. In order to predict the potent

SUBMITTER: Ye DX 

PROVIDER: S-EPMC6829842 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature