Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3^-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice.

ABSTRACT: High salt (HS) dietary intake leads to impaired vascular endothelium-dependent responses to various physiological stimuli, some of which are mediated by arachidonic acid (AA) metabolites. Transgenic Tff3^-/- gene knockout mice (Tff3^-/-/C57BL/6N) have changes in lipid metabolism which may affect vascular function and outcomes of stroke. We aimed to study the effects of one week of HS diet (4% NaCl) on vascular function and stroke induced by transient occlusion of middle cerebral artery in Tff3^-/- and wild type (WT/C57BL/6N) mice. Flow-induced dilation (FID) of carotid artery was reduced in WT-HS mice, but not affected in Tff3^-/--HS mice. Nitric oxide (NO) mediated FID. NO production was decreased with HS diet. On the con

SUBMITTER: Kozina N 

PROVIDER: S-EPMC6829871 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature