Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.

ABSTRACT: The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, b

SUBMITTER: Hernandez AR 

PROVIDER: S-EPMC6829909 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature