An observational study of pediatric healthcare burden in Angelman syndrome: results from a real-world study.

ABSTRACT: BACKGROUND:The objective of this study is to describe variations in the healthcare resource utilization (HRU) among individuals with Angelman syndrome (AS) over the first 12 years of life. Data for this study were drawn from the AS Natural History study (ASNHS), which is an observational study on the developmental progress, behavior, and medical morbidity of individuals with AS conducted over eight years. Caregiver-reported information on hospitalization, surgery, and medication utilization was used to assess HRU. Repeated measures mixed effect models were used to assess the relationship between age and probability of hospitalization, surgery, and prescription medication utilization. RESULTS:Mean age at study enrollment was 6 years of age and both sexes were equally represented. The mean n

SUBMITTER: Khan N 

PROVIDER: S-EPMC6829925 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature