Local application of doxorubicin- loaded Iron oxid nanoparticles and the vascular disrupting agent via the hepatic artery: chemoembolization-photothermal ablation treatment of hepatocellular carcinoma in rats.

ABSTRACT:

Objectives

This study investigates the effectiveness of local application of doxorubicin(Dox)-loaded, polydopamine (PDA)- coated single crystal hematite (α- Fe₂O₃) nanocubes (Fe₂O₃-PDA-Dox) and combretastatin A-4 phosphate disodium(CA4P)in treating hepatocellular carcinoma (HCC) in rats.

Methods

The magnetic characteristics and photothermal effects of the nanoparticles were determined in vitro. Tumor-bearing Sprague-Dawley rats were divided into 3 groups of 8 according to treatment: controls, transarterial chemoembolization-photothermal ablation (pTACE) (Lipidol+Fe₂O₃-PDA-Dox + NIR), and CA4P + pTACE (CA4P+ Lipidol+Fe₂O₃-PDA-Dox + NIR). Drugs were administered through the hepatic artery,

SUBMITTER: Yuan H 

PROVIDER: S-EPMC6829940 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature