Whole-genome sequencing of ocular Chlamydia trachomatis isolates from Gadarif State, Sudan.

ABSTRACT:

Background

Trachoma, caused by ocular Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. Sudan first reported trachoma in the 1930s and has since been consistently endemic. Ocular C. trachomatis previously isolated from trachoma patients in Sudan in 1963 was antigenically identical to an isolate from Saudi Arabia (A/SA1). No contemporary ocular C. trachomatis whole genome sequences have been reported from Sudan.

Methods

This study sequenced twenty ocular C. trachomatis isolates to improve understanding of pathogen diversity in North-East Africa and examine for genomic variation specific to Sudan, possibly related to the persistence of trachoma in surveyed communities. High quality, whole genome sequences were obtained from 12/20 isolates.

Resul

SUBMITTER: Alkhidir AAI 

PROVIDER: S-EPMC6829945 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature