A comparative study of topology-based pathway enrichment analysis methods.

ABSTRACT:

Background

Pathway enrichment extensively used in the analysis of Omics data for gaining biological insights into the functional roles of pre-defined subsets of genes, proteins and metabolites. A large number of methods have been proposed in the literature for this task. The vast majority of these methods use as input expression levels of the biomolecules under study together with their membership in pathways of interest. The latest generation of pathway enrichment methods also leverages information on the topology of the underlying pathways, which as evidence from their evaluation reveals, lead to improved sensitivity and specificity. Nevertheless, a systematic empirical comparison of such methods is still lacking, making selection of the most suitable method for a specific experi

SUBMITTER: Ma J 

PROVIDER: S-EPMC6829999 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature