Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications.

ABSTRACT: Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant preclinical and clinical literature accumulating over the past two decades. However, the therapeutic potential of DC-targeting approaches remains to be fully exploited in the clinic. Here, we discuss the unique features of DCs that underlie the high therapeutic potential of DC-targeting stra

SUBMITTER: Fucikova J 

PROVIDER: S-EPMC6830192 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature