Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?

ABSTRACT: Chronic liver diseases constitute a significant economic, social, and biomedical burden. Among commonly adopted approaches, only organ transplantation can radically help patients with end-stage liver pathologies. Cell therapy with hepatocytes as a treatment for chronic liver disease has demonstrated promising results. However, quality human hepatocytes are in short supply. Stem/progenitor cells capable of differentiating into functionally active hepatocytes provide an attractive alternative approach to cell therapy for liver diseases, as well as to liver-tissue engineering, drug screening, and basic research. The application of methods generally used to isolate mesenchymal stem cells (MSCs) and maintain them in culture to human liver tissue provides cells, designated here as liver MSCs. Th

SUBMITTER: Kholodenko IV 

PROVIDER: S-EPMC6830330 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature