Association of Adverse Experiences and Exposure to Violence in Childhood and Adolescence With Inflammatory Burden in Young People.

ABSTRACT:

Importance

Childhood stress exposure is associated with inflammation as measured by C-reactive protein (CRP) and interleukin 6 (IL-6). However, findings are inconsistent and effect sizes are small. The addition of soluble urokinase plasminogen activator receptor (suPAR), a new biomarker of chronic inflammation, may improve measurement of stress-related inflammatory burden.

Objectives

To assess whether exposure to adverse experiences, stress, and violence is associated with an increase in suPAR levels in young people and to test the hypothesis that measuring suPAR in addition to CRP or IL-6 levels improves the assessment of the inflammatory burden associated with early-life stress.

Design, setting, and participants

This cohort study included 1391 participants from a 19

SUBMITTER: Rasmussen LJH 

PROVIDER: S-EPMC6830440 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature