Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.

ABSTRACT: Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt(II) bond to an As(III) hydroxide center. Screens of the NCI-60 human tumor cell lines reveal that arsenoplatin-1 (AP-1), [Pt(μ-NHC(CH₃)O)₂ClAs(OH)₂], the first representative of this novel class of anticancer agents, displays a superior activity profile relative to the parent drugs As₂O₃ or cisplatin in a majority of cancer cell lines tested. These activity profiles are important because the success of arsenic trioxide in blood cancers (such as APL) has not been seen in solid tumors due to the rapid clearance of arsenous acid from the body. To understand the biological chemistry of these compounds, we evaluated interac

SUBMITTER: Miodragovic Đ 

PROVIDER: S-EPMC6830503 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature