Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance.

ABSTRACT:

Purpose

The purpose of the study is to develop an algorithm to identify pregnancies in administrative databases and apply it to assess pregnancy rates and outcomes in women prescribed isotretinoin or tretinoin.

Methods

Using the 2011 to 2015 Truven Health MarketScan Database, we identified pregnancies, including losses and terminations. In a cohort design, nonpregnant women filling a prescription for isotretinoin or tretinoin were matched to five women without either prescription. Women were followed for 365 days or until conception, medication discontinuation, or enrollment discontinuation ("prescription episode"). Rates of pregnancy, risks of pregnancy losses, and prevalence of infant malformations at birth were assessed by exposure.

Results

We identified 2 179 192

SUBMITTER: MacDonald SC 

PROVIDER: S-EPMC6830505 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature