Effects of intraoperative PEEP on postoperative pulmonary complications in high-risk patients undergoing laparoscopic abdominal surgery: study protocol for a randomised controlled trial.

ABSTRACT:

Introduction

Postoperative pulmonary complications (PPCs), strongly associated with higher mortality risk, can develop in up to 58% of patients undergoing abdominal surgery. More and more evidence shows that the use of a lung-protective ventilation strategy has a lung protection effect in patients undergoing abdominal surgery, however, the role of positive end-expiratory pressure (PEEP) during the intraoperative period in preventing PPCs for laparoscopic surgery is not clearly defined.

Methods and analysis

A total of 208 patients with a high risk of PPC, undergoing laparoscopic abdominal surgery, will be enrolled and randomised into a standard PEEP (6-8 cm H₂O) group and a low PEEP (≤2 cm H₂O) group. Both groups will receive a fraction of inspired oxyge

SUBMITTER: Zhou ZF 

PROVIDER: S-EPMC6830676 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature