Female reproductive history in relation to chronic obstructive pulmonary disease and lung function in UK biobank: a prospective population-based cohort study.

ABSTRACT:

Objectives

Sex differences in respiratory physiology and predilection for developing chronic obstructive pulmonary disease (COPD) have been documented, suggesting that female sex hormones may influence pathogenesis. We investigated whether aspects of female reproductive health might play a role in risk of COPD among women.

Design

Population-based prospective cohort study.

Setting

UK Biobank recruited across 22 centres in the UK between 2006 to 2010.

Primary and secondary outcomes measures

We examined a range of female reproductive health indicators in relation to risk of COPD-related hospitalisation/death (n=271 271) using Cox proportional hazards regression; and lung function (n=273 441) using linear regression.

Results

Parity >3 was associated with gre

SUBMITTER: Tang R 

PROVIDER: S-EPMC6830692 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature