The association of tryptophan and phenylalanine are associated with arsenic-induced skin lesions in a Chinese population chronically exposed to arsenic via drinking water: a case-control study.

ABSTRACT:

Objectives

We investigated the association of specific serum amino acids (AAs) with the odds of arsenic-induced skin lesions (AISL) and their ability to distinguish patients with AISL from people chronically exposed to arsenic.

Design

Case-control study.

Setting

Three arsenic-exposed villages in Wuyuan County, Hetao Plain, Inner Mongolia, China were evaluated.

Participants

Among the 450 residents aged 18-79 years, who were chronically exposed to arsenic via drinking water, 56 were diagnosed as having AISL (defined as cases). Another 56 participants without AISL, matched by gender and age (±1 year) from the same population, were examined as controls.

Main outcome measures and methods

AA levels were determined by ultra-high-performance liquid chromatograph

SUBMITTER: Wei Y 

PROVIDER: S-EPMC6830718 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature