Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients.

ABSTRACT: INTRODUCTION AND HYPOTHESIS:Persistent and de novo symptoms decrease satisfaction after urogynecologic surgery. We investigated whether the preoperative bladder microbiome is associated with urinary symptoms prior to and after urogynecologic surgery. METHODS:One hundred twenty-six participants contributed responses to the validated OABq symptom questionnaire. Catheterized (bladder) urine samples and vaginal and perineal swabs were collected immediately preoperatively. Bacterial DNA in the urine samples and swabs was sequenced and classified. RESULTS:Preoperative symptom severity was significantly worse in sequence-positive patients. Higher OABq Symptom Severity (OABqSS) scores (more symptomatic) were associated with higher abundance in bladder urine of two bacterial species: Atopobium vagi

SUBMITTER: Fok CS 

PROVIDER: S-EPMC6830733 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature