Influence of Mortality on Estimating the Risk of Kidney Failure in People with Stage 4 CKD.

ABSTRACT:

Background

Most kidney failure risk calculators are based on methods that censor for death. Because mortality is high in people with severe, nondialysis-dependent CKD, censoring for death may overestimate their risk of kidney failure.

Methods

Using 2002-2014 population-based laboratory and administrative data for adults with stage 4 CKD in Alberta, Canada, we analyzed the time to the earliest of kidney failure, death, or censoring, using methods that censor for death and methods that treat death as a competing event factoring in age, sex, diabetes, cardiovascular disease, eGFR, and albuminuria. Stage 4 CKD was defined as a sustained eGFR of 15-30 ml/min per 1.73 m².

Results

Of the 30,801 participants (106,447 patient-years at risk; mean age 77 years), 18% d

SUBMITTER: Ravani P 

PROVIDER: S-EPMC6830798 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature