Associations between vitamin D receptor genetic variants and tuberculosis: a meta-analysis.

ABSTRACT: We performed a meta-analysis to evaluate potential associations between vitamin D receptor ( VDR) genetic variants and tuberculosis (TB). Systematic literature research was conducted in PubMed, Web of Science, and Embase. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations in all possible genetic models, and P values ≤ 0.05 were considered to be statistically significant. In total, 42 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: P = 0.02; allele model: P = 0.03) and rs731236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 (dominant and alle

SUBMITTER: Xu X 

PROVIDER: S-EPMC6830906 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature