Mammalian cell entry operons; novel and major subset candidates for diagnostics with special reference to Mycobacterium avium subspecies paratuberculosis infection.

ABSTRACT: Mammalian cell entry (mce) genes are the components of the mce operon and play a vital role in the entry of Mycobacteria into the mammalian cell and their survival within phagocytes and epithelial cells. Mce operons are present in the DNA of Mycobacteria and translate proteins associated with the invasion and long-term existence of these pathogens in macrophages. The exact mechanism of action of mce genes and their functions are not clear yet. However, with the loss of these genes Mycobacteria lose their pathogenicity. Mycobacterium avium subspecies paratuberculosis (MAP), the etiological agent of Johne's disease, is the cause of chronic enteritis of animals and significantly affects economic impact on the livestock industry. Since MAP is not inact

SUBMITTER: Hemati Z 

PROVIDER: S-EPMC6830979 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature