A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.

ABSTRACT:

Background

To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT).

Methods

A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically.

Results

However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0.94 [0.82-1.06] at day 28; 0.73 [0.36-1.47] at day 90; 1.16 [0.78-1.71] at 6 months; respectively). Selenium supplementation did not show favorable efficacy in the incidence of renal failure, secondary infection or duration of mechanical ventilation (RR [95% CI]: 0.65 [0.41-1.03]; 0.96 [0.87-1.06]; standard mean dif

SUBMITTER: Li S 

PROVIDER: S-EPMC6831114 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature