The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth.

ABSTRACT: Recent evidence suggests that numerous long non‑coding RNAs (lncRNAs) are dysregulated in cancer, and have critical roles in tumour development and progression. The present study investigated the ghrelin receptor antisense lncRNA growth hormone secretagogue receptor opposite strand (GHSROS) in breast cancer. Reverse transcription‑quantitative polymerase chain reaction revealed that GHSROS expression was significantly upregulated in breast tumour tissues compared with normal breast tissue. Induced overexpression of GHSROS in the MDA‑MB‑231 breast cancer cell line significantly increased cell migration in vitro, without affecting cell proliferation, a finding similar to our previous study on lung cancer cell lines. Microarray analysis revealed a significant repression of a small cluster of m

SUBMITTER: Thomas PB 

PROVIDER: S-EPMC6831199 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature