A novel prognostic model for diagnosing atypical bile duct hyperplasia in patients with intrahepatic lithiasis.

ABSTRACT: There is no specific method for the preoperative diagnosis of atypical bile duct hyperplasia, which is a precursor of cholangiocarcinoma. This study aimed to create a new model for diagnosing atypical bile duct hyperplasia based on routine laboratory tests in patients with intrahepatic lithiasis.The new diagnostic model was developed with a derivation cohort that included 375 patients with intrahepatic lithiasis. Clinical and pathological data were retrospectively collected. Prognostic factors were evaluated with univariate and logistic regression analyses. The validation cohort included 136 patients who were retrospectively screened to quantify the model's predictive value.Age and Carbohydrate Antigen 19-9 (CA-199) were revealed to be diagnostic indicators of atypical bile duct hyperplasi

SUBMITTER: Lu H 

PROVIDER: S-EPMC6831388 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature