Haploidentical Stem Cell Transplantation in Children With Hematological Malignancies Using αβ⁺ T-Cell Receptor and CD19⁺ Cell Depleted Grafts: High CD56^dim/CD56^bright NK Cell Ratio Early Following Transplantation Is Associated With Lower Relapse Incidence and Better Outcome.

ABSTRACT: We prospectively analyzed outcomes of haploidentical hematopoietic stem cell transplantation using αβ⁺ T-cell receptor/CD19⁺ depleted grafts. Sixty-three transplantations were performed in 60 patients. Twenty-eight patients were diagnosed with acute lymphoblastic leukemia (ALL), 27 patients were diagnosed with acute myelogenous leukemia, and in eight other hematological malignancies were diagnosed. Twenty-three were in first complete remission (CR), 20 in second CR, 20 beyond second CR. Four patients developed graft failure. Median time to neutrophil and platelet recovery was 14 (range 9-25) and 10 days (range 7-30), respectively. The probability of non-relapse mortality (NRM) by day +100 after transplantation was 10 ± 4%. With a median follow-up of 28 months, the pro

SUBMITTER: Diaz MA 

PROVIDER: S-EPMC6831520 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature