Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.

ABSTRACT: Spinal cord injury (SCI) is caused by an initial mechanical insult followed by a series of deleterious events that promote the progressive damage of affected tissues. Fibrinolysis, the process by which plasmin degrades cross-linked fibrin clots, has numerous functions in the central nervous system. However, the roles of the fibrinolytic system in SCI pathophysiology remain unknown. We investigated the roles of fibrinolysis in SCI, and explored therapeutic applications targeting fibrinolysis. Plasminogen-deficient (Plg^-/-) mice exhibited significantly improved locomotor function in the early phase of SCI (the first 7 days post injury), with significant inhibition of bleeding and vascular permeability, but failed to demonstrate conclusive functional recovery. Consistent with these

SUBMITTER: Shiraishi Y 

PROVIDER: S-EPMC6831600 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature