Trpc1 as the Missing Link Between the Bmp and Ca²⁺ Signalling Pathways During Neural Specification in Amphibians.

ABSTRACT: In amphibians, the inhibition of bone morphogenetic protein (BMP) in the dorsal ectoderm has been proposed to be responsible for the first step of neural specification, called neural induction. We previously demonstrated that in Xenopus laevis embryos, the BMP signalling antagonist, noggin, triggers an influx of Ca²⁺ through voltage-dependent L-type Ca²⁺ channels (LTCCs), mainly via Ca_V1.2, and we showed that this influx constitutes a necessary and sufficient signal for triggering the expression of neural genes. However, the mechanism linking the inhibition of BMP signalling with the activation of LTCCs remained unknown. Here, we demonstrate that the transient receptor potential canonical subfamily member 1, (Trpc1), is an intermediate between BMP receptor

SUBMITTER: Neant I 

PROVIDER: S-EPMC6831629 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature