Characterization of local and circulating bovine γδ T cell responses to respiratory BCG vaccination.

ABSTRACT: The Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccine is administered parenterally to infants and young children to prevent tuberculosis (TB) infection. However, the protection induced by BCG is highly variable and the vaccine does not prevent pulmonary TB, the most common form of the illness. Until improved TB vaccines are available, it is crucial to use BCG in a manner which ensures optimal vaccine performance. Immunization directly to the respiratory mucosa has been shown to promote greater protection from TB in animal models. γδ T cells play a major role in host defense at mucosal sites and are known to respond robustly to mycobacterial infection. Their positioning in the respiratory mucosa ensures their engagement in the response to aerosolized TB vaccination. However, our un

SUBMITTER: Guerra-Maupome M 

PROVIDER: S-EPMC6831659 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature