Current Insights in the Application of Bone Grafts for Local Antibiotic Delivery in Bone Reconstruction Surgery.

ABSTRACT: Introduction: Bone implant related infection is still one of the biggest challenges in bone and joint surgery. Antibiotic impregnated bone grafts seem to be promising in both treatment and prevention of these infections. However, great variance in methodology predominates this field of research. This paper gives an overview of the published literature. Methods: The PRISMA-flowchart was used as protocol for article selection. Medline was searched and articles were selected in accordance with predetermined exclusion criteria. Results: Forty-eight articles were included in the synthesis. Topics including bone graft type, manipulations of the graft, elution profile, bacterial inhibition, osteotoxicity, incorporation, special impregnation methods, clinical use and storage were investigated. The

SUBMITTER: Peeters A 

PROVIDER: S-EPMC6831806 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature