α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury.

ABSTRACT:

Objective

Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide and new treatment strategies are highly sought-after. Paradoxically, reperfusion of the ischemic myocardium, as achieved with early percutaneous intervention, results in substantial damage to the heart (ischemia/reperfusion injury) caused by cell death due to aggravated inflammatory and oxidative stress responses. Chronic therapy with vitamin E is not effective in reducing the cardiovascular event rate, presumably through failing to reduce atherosclerotic plaque instability. Notably, acute treatment with vitamin E in patients suffering a MI has not been systematically investigated.

Methods and results

We applied alpha-tocopherol (α-TOH), the strongest anti-oxidant form of vitamin E,

SUBMITTER: Wallert M 

PROVIDER: S-EPMC6831864 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature