Redox responses in skeletal muscle following denervation.

ABSTRACT: Previous studies have shown a significant increase in the mitochondrial generation of hydrogen peroxide (H₂O₂) and other peroxides in recently denervated muscle fibers. The mechanisms for generation of these peroxides and how the muscle responds to these peroxides are not fully established. The aim of this work was to determine the effect of denervation on the muscle content of proteins that may contribute to mitochondrial peroxide release and the muscle responses to this generation. Denervation of the tibialis anterior (TA) and extensor digitorum longus (EDL) muscles in mice was achieved by surgical removal of a small section of the peroneal nerve prior to its entry into the muscle. An increase in mitochondrial peroxide generation has been observed from 7 days and su

SUBMITTER: Scalabrin M 

PROVIDER: S-EPMC6831873 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature