Gray matter abnormalities in language processing areas and their associations with verbal ability and positive symptoms in first-episode patients with schizophrenia spectrum psychosis.

ABSTRACT:

Background

Impaired verbal communication is a prominent feature in patients with schizophrenia. Verbal communication difficulties adversely affect psychosocial outcomes and worsen schizophrenia's clinical manifestation. In the present study, we aimed to investigate associations among gray matter (GM) volumes in language processing areas (LPAs), verbal ability, and positive symptoms in first-episode patients (FEPs) with schizophrenia spectrum psychosis.

Methods

We enrolled 94 FEPs and 52 healthy controls (HCs) and subjected them to structural magnetic resonance imaging. The GM volumes of the bilateral pars opercularis (POp), pars triangularis (PTr), planum temporale (PT), Heschl's gyrus (HG), insula, and fusiform gyrus (FG), were estimated and compared between the FEPs and HC

SUBMITTER: Jung S 

PROVIDER: S-EPMC6831896 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature