Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder.

ABSTRACT:

Background

Subcortical nuclei are important components in the pathology model of obsessive-compulsive disorder (OCD), and subregions of these structures subserve different functions that may distinctively contribute to OCD symptoms. Exploration of the subregional-level profile of structural abnormalities of these nuclei is needed to develop a better understanding of the neural mechanism of OCD.

Methods

A total of 83 medication-free, non-comorbid OCD patients and 93 age- and sex-matched healthy controls were recruited, and high-resolution T1-weighted MR images were obtained for all participants. The volume and shape of the subcortical nuclei (including the nucleus accumbens, amygdala, caudate, pallidum, putamen and thalamus) were quantified and compared with an automated parc

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6831899 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature