Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.

ABSTRACT:

Objectives

Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear.

Methods

Full-term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis.

Results

In this study, each woman exhibited a unique immune response with raised IL-1RA, IP-10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS3 antigens co-localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF2 signalling, mitochondrial dysfunction and

SUBMITTER: Lum FM 

PROVIDER: S-EPMC6831931 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature