Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

ABSTRACT:

Objective

To characterize individual and group-level neuroimaging findings in patients at risk for Chronic Traumatic Encephalopathy (CTE).

Methods

Eleven male patients meeting criteria for Traumatic Encephalopathy Syndrome (TES, median age: 64) underwent neurologic evaluation, 3-Tesla MRI, and PET with [¹⁸F]-Flortaucipir (FTP, tau-PET) and [¹¹C]-Pittsburgh compound B (PIB, amyloid-PET). Six patients underwent [¹⁸F]-Fluorodeoxyglucose-PET (FDG, glucose metabolism). We assessed imaging findings at the individual patient level, and in group-level comparisons with modality-specific groups of cognitively normal older adults (CN). Tau-PET findings in patients with TES were also compared to a matched group of patients with mild cognitive impairment

SUBMITTER: Lesman-Segev OH 

PROVIDER: S-EPMC6831941 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature