Ontology highlight
ABSTRACT:
SUBMITTER: Sakamoto K
PROVIDER: S-EPMC6832012 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sakamoto Kenichi K Furuichi Yasuro Y Yamamoto Masashi M Takahashi Megumi M Akimoto Yoshihiro Y Ishikawa Takahiro T Shimizu Takahiko T Fujimoto Masanori M Takada-Watanabe Aki A Hayashi Aiko A Mita Yoshitaka Y Manabe Yasuko Y Fujii Nobuharu L NL Ishibashi Ryoichi R Maezawa Yoshiro Y Betsholtz Christer C Yokote Koutaro K Takemoto Minoru M
EMBO reports 20190916 11
In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml ...[more]