A Systematic Review of Evidence for a Role of Rest-Activity Rhythms in Dementia.

ABSTRACT: Background: Rest-activity rhythm (RAR) disruption may be a risk factor for dementia that can be objectively measured with wearable accelerometers. It is possible that risk monitoring and preventive interventions could be developed targeting RARs. To evaluate whether current evidence supports these applications, we systematically reviewed published studies linking RARs with dementia, its course, and mechanisms. Methods: Entering pre-defined search terms in PsycINFO, MEDLINE, and PubMed databases returned 192 unique titles. We identified 32 articles that met our primary inclusion criteria, namely, that they examined objective RAR measures in the context of dementia, cognition, or brain biomarkers. Results: Cross-sectional studies consistently found that people with demen

SUBMITTER: Smagula SF 

PROVIDER: S-EPMC6832024 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature