Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis.

ABSTRACT: BACKGROUND AND OBJECTIVES:In 2012, the Systemic Lupus International Collaborating Clinics proposed that lupus nephritis, in the presence of positive ANA or anti-dsDNA antibody, is sufficient to diagnose SLE. However, this "stand-alone" kidney biopsy criterion is problematic because the ISN/RPS classification does not specifically define lupus nephritis. We investigated the combination of pathologic features with optimal sensitivity and specificity for the diagnosis of lupus nephritis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:Three hundred consecutive biopsies with lupus nephritis and 560 contemporaneous biopsies with nonlupus glomerulopathies were compared. Lupus nephritis was diagnosed if there was a clinical diagnosis of SLE and kidney biopsy revealed findings compatible with lupus

SUBMITTER: Kudose S 

PROVIDER: S-EPMC6832038 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature