Serum Calcification Propensity and Clinical Events in CKD.

ABSTRACT:

Background and objectives

Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcification is one pathway through which cardiovascular disease risks are increased. We hypothesized that a novel measure of serum calcification propensity is associated with cardiovascular disease events, ESKD, and all-cause mortality among patients with CKD stages 2-4.

Design, setting, participants, & measurements

Among 3404 participants from the prospective, longitudinal Chronic Renal Insufficiency Cohort Study, we quantified calcification propensity as the transformation time (T₅₀) from primary to secondary calciprotein particles, with lower T₅₀ corresponding to higher calcification propensity. We used multivariable-adjusted Cox p

SUBMITTER: Bundy JD 

PROVIDER: S-EPMC6832040 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature