A Combined Score of Circulating miRNAs Allows Outcome Prediction in Critically Ill Patients.

ABSTRACT:

Background and aims

Identification of patients with increased risk of mortality represents an important prerequisite for an adapted adequate and individualized treatment of critically ill patients. Circulating micro-RNA (miRNA) levels have been suggested as potential biomarkers at the intensive care unit (ICU), but none of the investigated miRNAs displayed a sufficient sensitivity or specificity to be routinely employed as a single marker in clinical practice.

Methods and results

We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. In this study, we re-analyzed these previously published data and performed a combined analysis of these markers to unravel

SUBMITTER: Roderburg C 

PROVIDER: S-EPMC6832199 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature