Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide.

ABSTRACT: The total synthesis of potent anti-obesity lansiumamide B was accomplished in four steps using commercially available materials. The synthetic strategy, featured with copper-catalyzed Buchwald coupling, is concise, convergent, practical and can be carried out on a one-gram scale. This approach could give either Z- or E-configured enamide moiety in natural products with absolute stereocontrol and was applied in the total synthesis of natural products.

SUBMITTER: Lin R 

PROVIDER: S-EPMC6832413 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature