G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives.

ABSTRACT: G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich oligonucleotides of DNA- or RNA-type. Depending on their chemical nature, loops length, and localization in the sequence or structure molecularity, G-quadruplexes are highly polymorphic structures showing various folding topologies. They may be formed in the human genome where they are believed to play a pivotal role in the regulation of multiple biological processes such as replication, transcription, and translation. Thus, natural G-quadruplex structures became prospective targets for disease treatment. The fast development of systematic evolution of ligands by exponential enrichment (SELEX) technologies provided a number of G-rich aptamers revealing the potential of G-quadruplex structures as a promisin

SUBMITTER: Roxo C 

PROVIDER: S-EPMC6832456 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature