Autophagy and Inflammasome Activation in Dilated Cardiomyopathy.

ABSTRACT: The clinical outcome of patients affected by dilated cardiomyopathy (DCM) is heterogeneous, since its pathophysiology is only partially understood. Interleukin 1β levels could predict the mortality and necessity of cardiac transplantation of DCM patients. To investigate mechanisms triggering sterile inflammation in dilated cardiomyopathy (DCM). Hearts explanted from 62 DCM patients were compared with 30 controls, employing immunohistochemistry, cellular and molecular biology, as well as metabolomics studies. Although misfolded protein accumulation and aggresome formation characterize DCM hearts, aggresomes failed to trigger the autophagy lysosomal pathway (ALP), with consequent accumulation of both p62SQSTM1 and dysfunctional mitochondria. In line, DCM hearts are characterized by accumulat

SUBMITTER: Caragnano A 

PROVIDER: S-EPMC6832472 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature